MovDisordV3, Main, Exploration, bibRecord, 006202

Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation

Identifieur interne : 006202 ( Main/Exploration ); précédent : 006201; suivant : 006203

Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation

Auteurs : Meyer [Allemagne] ; T. C. Britton [Allemagne] ; C. Bischoff [Allemagne] ; J. Machetanz [Allemagne] ; R. Benecke [Allemagne] ; B. Conrad [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 1991.

RBID : ISTEX:887C1BD18DCBEEFF2A52BEDA62EEA409C8B0F6A7

English descriptors

KwdEn :
- Adult, Electromagnetic Fields, Electromyography, Follow-Up Studies, Hepatolenticular Degeneration (diagnosis), Hepatolenticular Degeneration (drug therapy), Hepatolenticular Degeneration (physiopathology), Humans, Motor Cortex (drug effects), Motor Cortex (physiopathology), Muscle Contraction (drug effects), Muscle Contraction (physiology), Muscles (innervation), Neurologic Examination, Penicillamine (therapeutic use), Pyramidal Tracts (drug effects), Pyramidal Tracts (physiopathology), Synaptic Transmission (drug effects), Synaptic Transmission (physiology), Wilson's disease, motor responses.
MESH :
- chemical , therapeutic use : Penicillamine.
- diagnosis : Hepatolenticular Degeneration.
- drug effects : Motor Cortex, Muscle Contraction, Pyramidal Tracts, Synaptic Transmission.
- drug therapy : Hepatolenticular Degeneration.
- innervation : Muscles.
- physiology : Muscle Contraction, Synaptic Transmission.
- physiopathology : Hepatolenticular Degeneration, Motor Cortex, Pyramidal Tracts.
- Adult, Electromagnetic Fields, Electromyography, Follow-Up Studies, Humans, Neurologic Examination.

Abstract

Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.

Url:

https://api.istex.fr/document/887C1BD18DCBEEFF2A52BEDA62EEA409C8B0F6A7/fulltext/pdf

DOI: 10.1002/mds.870060409

Affiliations:

Le document en format XML

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<term>Hepatolenticular Degeneration (drug therapy)</term>
<term>Hepatolenticular Degeneration (physiopathology)</term>
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<term>Muscle Contraction (physiology)</term>
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<term>Pyramidal Tracts (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.</div>
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Movement Disorders (revue)

Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation

Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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